The Smithton Inn is located on Main Street (US 322) at the junction of South Academy Drive in the borough of Ephrata.

From the PA Turnpike:
Take Exit 21 and follow Route 222 South to the Ephrata Exit; turn right on US 322 West. Travel approximately four miles through Ephrata. Drive under PA 272 and continue to the traffic light at South Academy Drive. Take a left at the light, then a right into our parking lot.

From Lancaster:
Travel North on Route 222 to the Ephrata Exit; turn left on US 322 West. Travel approximately four miles through Ephrata. Drive under PA 272 and continue to the traffic light at South Academy Drive. Take a left at the light, then a right into our parking lot.